Fig. 1: Specific deletion of the canonical MYO7A-C isoform. | Nature Communications

Fig. 1: Specific deletion of the canonical MYO7A-C isoform.

From: Myosin-VIIa is expressed in multiple isoforms and essential for tensioning the hair cell mechanotransduction complex

Fig. 1

a Scanning electron micrographs depicting IHCs and OHCs in the mouse organ of Corti, and a schematic illustration of the proposed function of MYO7A at the upper tip-link density of the mechanotransduction complex (scale bars: 5 μm in overview SEM, and 1 μm in OHC and IHC SEMs). b, c Graphical illustration of the canonical and the presumed short MYO7A protein isoforms (MYO7A-C and MYO7A-S, respectively) and corresponding genomic structures. The site of the deleterious mutation in the Myo7a-ΔC mouse is indicated. d Sanger sequencing result of the heterozygous Myo7a-ΔC founder mouse. An adenine insertion (shown in red) introduces a deleterious mutation in the reading frame of Myo7a-C. Sequencing was performed from the reverse direction.

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