Fig. 5: Loss of PBRM1 function was associated with increased angiogenesis. | Nature Communications

Fig. 5: Loss of PBRM1 function was associated with increased angiogenesis.

From: PBRM1 loss defines a nonimmunogenic tumor phenotype associated with checkpoint inhibitor resistance in renal carcinoma

Fig. 5

a Correlogram between the expression of immunomodulatory and angiogenic genes IMmotion 150 cohort (top line of each square), TCGA cohort (middle line of each square) and ICGC cohort (bottom line of each square). b Patients with mutant PBRM1 demonstrated increased CD31 immunostaining levels in the IMmotion150 cohort. Rank-sum test. c CD31 immunostaining levels positively correlated with angiogenesis expression score. Spearman correlation and associated P-value inset (N = 119). d PBRM1 mutated tumors were associated with increased angiogenesis score in 3 indicated patient cohorts. Rank-sum test. e Pbrm1 knockout was associated with increased angiogenesis score in pre-malignant murine kidneys. Student t-test. f Pbrm1 knockout Renca tumors demonstrated increased CD31 immunostaining levels. Student t-test. Data in the bar graphs represent mean ± S.D. Source data are provided as a Source Data file.

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