Fig. 1: Structure and interaction properties of DIPs and Dprs.
From: DIP/Dpr interactions and the evolutionary design of specificity in protein families
a Ribbon representation of the DIP/Dpr heterodimer (PDBID: 6EG0)11—DIP shown in cyan, Dpr in pink. b Affinity-based binding interactome of DIPs and Dprs of Drosophila melanogaster. Line thickness indicates the KD for a given pairwise interaction, as specified in the boxed inset. Groupings are color-coded based on their heterophilic binding preference. The interactome is based on previously published SPR data11. c Structural alignment of Ig1 domains in DIP/Dpr complexes (see Methods section for PDBIDs). DIPs and Dprs interact via their CC′C″FG surfaces.
