Fig. 5: Negative constraints in DIP/Dpr non-cognate pairs.
From: DIP/Dpr interactions and the evolutionary design of specificity in protein families
Negative constraints in three DIP/Dpr subfamilies predicted using the protocol are shown on the DIP (in cyan) and Dpr (in pink) interacting surfaces of purple, blue, and green subfamilies using an open book representation, with cognate interacting pairs shown enclosed in boxes coded with subfamily color. Family-wide interfacial position number are in filled white boxes. Amino acid residue identity at a negative constraint position is given in a one letter code. The physical origin of each negative constraint is shown with a pictogram as detailed in the enclosed rectangle at bottom.
