Fig. 6: Predicted positions of negative constraints in DIP/Dpr subgroups.
From: DIP/Dpr interactions and the evolutionary design of specificity in protein families
Logos created for Insecta with residues that function as negative constraints highlighted in gray. Subfamily color-code as in Fig. 1b. Each interfacial position (1–33) is annotated above logos with associated secondary structure, as detailed in the boxed legend. Sequence-based predictions of specificity determining positions using GroupSim, SDPpred, SPEER, and Multi-Harmony methods (same as in Fig. 2a) are given below logos as specified in boxed inset.
