Table 5 Urine Cr-normalized biomarkers in the second (Chinese) validation cohort.

From: Comprehensive aptamer-based screening identifies a spectrum of urinary biomarkers of lupus nephritis across ethnicities

Urine protein

Fold-changea

 

Active/inactive

AR/ANR

SLE/healthy

Comparison of active LN vs inactive SLEa

Cut-off

ROC AUC

Sens.

Spec.

NPV

PPV

ALCAM

14****

4.3****

10.8****

15K

0.93****

0.9

0.91

0.9

0.91

Calpastatin

7.1****

3.1****

3.3

0

0.74****

0.66

0.78

0.7

0.75

Hemopexin

2.3****

1.1

2.6****

630K

0.74****

0.85

0.56

0.79

0.66

Peroxiredoxin-6

6.6****

1.8*

3.4****

0

0.75****

0.56

0.91

0.68

0.87

PF-4

24****

1.8**

11****

0

0.83****

0.74

0.88

0.77

0.86

Properdin

13****

10.8****

26

0

0.74****

0.61

0.84

0.68

0.79

TFPI

6.2****

2.4****

4.9****

200

0.88****

0.8

0.89

0.82

0.89

VCAM-1

8.9****

2.0****

21****

30,200

0.92****

0.9

0.88

0.9

0.88

 C3

0.5****

0.8***

N/A

13

0.12

1

0

0

0.5

 C4

0.5****

0.8**

N/A

3

0.19

1

0

0

0.5

 Anti-DNA

2.4****

1.3**

N/A

215

0.82****

0.63

0.99

0.98

0.72

  1. The cohort comprises 80 inactive SLE patients, 67 active non-renal (ANR),
  2. 80 active LN patients, and 53 healthy controls.
  3. Source data are provided as a Source Data file.
  4. ap-values by Mann–Whitney U-test (*p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001).
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