Fig. 4: Maps for the significant associations between depression-PRS and brain phenotypes. | Nature Communications

Fig. 4: Maps for the significant associations between depression-PRS and brain phenotypes.

From: A phenome-wide association and Mendelian Randomisation study of polygenic risk for depression in UK Biobank

Fig. 4

a–c are the brain maps for the significant associations between depression-PRS and white matter microstructure in fractional anisotropy (FA; a), mean diffusivity (MD; b) and intra-cellular volume fraction (ICVF; c) of major tracts. The shade for each tract represents the standardised effect size (β), with a darker shade showing a greater mean β across all depression-PRS at different p thresholds (pT). From left to right are from anterior, superior and right view. For clarity, among the tracts presented in Fig. 2, the ones that showed consistent associations across at least four depression-PRS pT are presented. d shows the brain maps for regions involved in significant associations between resting-state fluctuation amplitude and depression-PRS. Regions that show consistent associations across at a minimum of four depression-PRS p thresholds are presented. Visualisation of results is achieved by calculating the average intensity of ICA maps, weighted by their mean β across the pT. For clarity, the brain maps shown below have a threshold applied on (intensity over 50% of the highest global intensity).

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