Table 1 A summary of phenotypes.

From: A phenome-wide association and Mendelian Randomisation study of polygenic risk for depression in UK Biobank

Category

Number of traits

N for Discovery sample

N for Replication sample

UK Biobank data modality

Mental health

44

Range: 3299–10,674; Mean: 7970

Range: 1519–5565; Mean: 3880

Touchscreen, Online follow-up

Sociodemographic

5

Range: 8054–9941; Mean: 8759

Range: 3824–5199; Mean: 4352

Touchscreen

Early-life risk factor

11

Range: 7428–10,674; Mean: 9775

Range: 8255–11,214; Mean: 10,370

Touchscreen, Online follow-up

Lifestyle measures

66

Range: 2789–10,674; Mean: 9231

Range: 1392–5565; Mean: 4796

Touchscreen

Physical measures

67

Range: 2155–10,674; Mean: 8961

Range: 1047–5565; Mean: 4618

Touchscreen

Cognitive ability

16

Range: 5250–10,674; Mean: 8153

Range: 2586–5565; Mean: 4105

Touchscreen, Online follow-up

Intracranial/subcortical volume

9

Range: 10,627–10,631; Mean: 10,631

Range: 5550–5553; Mean: 5553

Brain imaging

White matter hyperintensity

8

9702

5187

Brain imaging

White matter microstructure

95

Range: 9341–9396; Mean: 9377

Range: 5187–5261; Mean: 5239

Brain imaging

Resting-state functional connectivity

210

9745

5241

Brain imaging

Resting-state fluctuation amplitude

21

9745

5241

Brain imaging

  1. A total of 209 behavioural phenotypes (6 categories) and 343 neuroimaging variables (4 categories) are included. Where there are multiple sample sizes in a category, a range and the mean of sample sizes (N) are presented.