Fig. 10: Ras/MAPK and PI3K/AKT co-recruitment is necessary for tumour extrusion. | Nature Communications

Fig. 10: Ras/MAPK and PI3K/AKT co-recruitment is necessary for tumour extrusion.

From: Sequential Ras/MAPK and PI3K/AKT/mTOR pathways recruitment drives basal extrusion in the prostate-like gland of Drosophila

Fig. 10

Initiation by a oncogenic hit (red) allows ERK activation in rare epithelial cells. This induces production of two growth factors in these cells, EGF/Spitz and IGF-Ilp6 (violet). EGF/Spitz re-activates ERK in an autocrine manner, via EGFR activation (amplification loop, blue). This sustains an increase in the growth factors production. Subsequently, EGFR/InR autocrine activation induces a coordinated recruitment of the Ras/MAPK and PI3K/AKT/TOR pathways. This finally allows formation of invasive tumours outside the epithelial compartment.

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