Fig. 4: Increased glucose metabolism in ARI-resistant cells depends on AR signalling.
From: 2,4-dienoyl-CoA reductase regulates lipid homeostasis in treatment-resistant prostate cancer
a Expression of labelled isotopologue of selected metabolites in ARI-resistant and WT LNCaP cells silenced for AR and following 1 h 13C-glucose incorporation. b Western blot analysis of AR, ACC and ACLY expression in WT and ARI-resistant LNCaP cells following AR siRNA silencing. HSC70 is used as a sample loading control. a Data are presented as mean values +/− SD, *p-value of labelled fraction < 0.05 using a 2-way ANOVA with a Sidak’s multiple comparisons test. DHAP dihydroxyacetone-phosphate, PEP phosphoenolpyruvate. Source data are provided as a Source data File.
