Fig. 4: Hypothetical Models for chiral insertion and regioselective insertion. | Nature Communications

Fig. 4: Hypothetical Models for chiral insertion and regioselective insertion.

From: NHC-Ni catalyzed enantioselective synthesis of 1,4-dienes by cross-hydroalkenylation of cyclic 1,3-dienes and heterosubstituted terminal olefins

Fig. 4

a Chiral NHC–Ni(II)H insertion to diene which give major enantiomer 3. b, c Unfavorable steric interactions among NHC and diene which disfavored the insertion. d Steric control regioselective insertion of terminal olefin. e Role of heteroatom in regioselective insertion of homoallylether.

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