Fig. 7: Model for the role of hnRNP H/F-RG4 interactions in regulating mRNA translation of mRNAs linked to GBM response to treatments. | Nature Communications

Fig. 7: Model for the role of hnRNP H/F-RG4 interactions in regulating mRNA translation of mRNAs linked to GBM response to treatments.

From: hnRNP H/F drive RNA G-quadruplex-mediated translation linked to genomic instability and therapy resistance in glioblastoma

Fig. 7

hnRNP H/F expression levels in GBM modulate the RG4-dependent mRNA translation impacting the DDR response involved in the response to standard GBM treatments (radiotherapy and chemotherapy). The underlying mechanism involves the binding of the helicase DHX36 that unwinds the RG4s, enabling hnRNP H/F to associate with unfolded RG4s and maintain them linear.

Back to article page