Fig. 3: Hypomyelination in APO-SUS versus APO-UNSUS mPFC. | Nature Communications

Fig. 3: Hypomyelination in APO-SUS versus APO-UNSUS mPFC.

From: Interneuron hypomyelination is associated with cognitive inflexibility in a rat model of schizophrenia

Fig. 3

a Electron microscopy analysis and quantification of the number of myelinated axons in IL, PL, and BC, and the percentage (%) of the total surface that represents axon in PL of APO-SUS (n = 3) and APO-UNSUS (n = 3) rats. Scale bars represents 1 µm. IL **p = 0.006 and PL *p = 0.047 in two-tailed independent samples t-test. b G-ratio versus axon caliber and the average G-ratio for all myelinated axons in IL and PL of APO-SUS (n = 4), and APO-UNSUS (n = 3) rats. c Representative high magnification electron microscopy images of the myelin ultrastructure in APO-SUS and APO-UNSUS IL. Scale bars a, c: 1 µm and 50 nm in insets. Myelin ultrastructure was examined in the IL of n = 3 APO-SUS and n = 3 APO-UNSUS rats. d IL axon caliber frequency distribution in APO-SUS versus APO-USNUS rats. *p = 0.040 in two-tailed independent samples t-test. Error bars represent standard error of the mean. Source data are provided as a Source data file.

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