Fig. 8: Environmental enrichment improves cognitive inflexibility of APO-SUS rats.

a Schematic representation of experimental paradigm. APO-SUS and APO-UNSUS rats were housed in standard housing or in environmental enrichment conditions starting at P21, and subjected to behavioral testing between P60 and P90. b Schematic representation of the extra-dimensional set-shifting task. Rats were trained to press the lever above which a cue light was illuminated. From trail 21 of the next session onward, rats were required to press the lever on one side of the cage irrespective of the cue light. Number of errors to criterion (streak of ten correct trials) and total number of perseverative, regressive, and never-reinforced errors in APO-UNSUS (n = 18) and APO-SUS (n = 20) rats in standard housing (the same data as are presented in Fig. 1b) and environmental enrichment (n = 10) are depicted. Note that between shift 2 and shift 3 the reversal learning trials were conducted (see Supplementary Fig. 5). Shift 2 **p = 0.001, shift 3 *p = 0.028, shift 3 ^p = 0.030, perseverative errors **p = 0.001, ^p = 0.036 in two-tailed multivariate ANOVA post hoc testing. Source data are provided as a Source data file.