Fig. 1: Gut microbiota composition differs between PWH and uninfected controls. | Nature Communications

Fig. 1: Gut microbiota composition differs between PWH and uninfected controls.

From: HIV-associated gut dysbiosis is independent of sexual practice and correlates with noncommunicable diseases

Fig. 1

a Alpha diversity measures are shown for all participants, grouped as PWH and seronegative controls (n = 142, two-tailed paired t-test P = 0.0012, P = 0.0012, P = 0.0004, respectively). Boxes denote inter-quartile range, bar denotes median, and whiskers denote range. b Principal coordinates analysis (PCoA) plot based on the Canberra beta diversity metric with centroids depicted as diamonds for PWH and seronegative controls. Community differences were verified by PERMANOVA, P = 0.001. c Volcano plot depicting ASVs (operational taxonomic units, referring to dada2 sequence variants) in differential abundance between PWH and seronegative controls using the paired non-parametric Wilcoxon signed-rank test, with pairs of PWH and controls matched for sex, sexual practice, age, BMI, and birth country. Benjamini–Hochberg false discovery rate Q-value cutoff of 0.05 is shown. ASVs are colored by either their family (for Lachnospiraceae, Ruminococcaceae, and Prevotellacaeae) or order (all else), and families of selected taxa are denoted by text. *P < 0.05, **P < 0.005, ***P < 0.001.

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