Fig. 4: Recent sexual practice and lifetime sexual practice impacts gut microbiota composition regardless of sex. | Nature Communications

Fig. 4: Recent sexual practice and lifetime sexual practice impacts gut microbiota composition regardless of sex.

From: HIV-associated gut dysbiosis is independent of sexual practice and correlates with noncommunicable diseases

Fig. 4

a Volcano plot depicting ASVs in differential abundance between MSM/RAI+ (men who have sex with men that experienced receptive anal intercourse within the last 6 months prior to sampling, n = 44) and MSM/RAI− (men who have sex with men that did not experience receptive anal intercourse within the last 6 months prior to sampling, n = 28), matched for infection status. b Overlap in abundance trends among the top 100 taxa in differential fold abundance among MSM vs. MSW (n = 72 MSM, n = 22 MSW) and MSM/RAI+ vs. MSM/RAI− (n = 44 MSM/RAI+, n = 28 MSM/RAI−). Mann–Whitney tests were performed on each ASV for both comparisons, and shown are taxa that reached P < 0.05 on both lists. c Average Canberra community distances to MSM/RAI+ were calculated for each female participant sample that reported receptive anal intercourse within 6 months prior to sampling (F/RAI+, n = 5) and female participants that reported no such activity (F/RAI−, n = 28). F/RAI+ gut communities were significantly more similar to MSM/RAI+ than were those for F/RAI−. Unpaired two-tailed t-test P = 0.0496. Middle bar denotes average and error bars represent SD. d Overlap in abundance trends among the taxa that reached P < 0.05 in both comparisons of MSM vs. MSW and F/RAI+ vs. F/RAI− (Fisher’s exact test P = 0.077), as performed in b.

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