Fig. 6: Reconstruction of evolutionary trajectories from SCNA and DNA methylation profiles.
From: Genetic and epigenetic intratumor heterogeneity impacts prognosis of lung adenocarcinoma
a Pairwise distance of tumor samples from the same tumor based on DNA methylation and SCNA profiles. Each dot represents a pair of tumor samples from the same subject. Significant Spearman’s correlation coefficient is shown (n = 212 tumor sample pairs). b Phylogenetic analysis of subject IGC-11-1044 based on DNA methylation and SCNA profiles, and the consensus phylogenetic tree built based on the distance incorporating both SCNA and DNA methylation profiles. Blue lines represent alterations shared by all tumor samples from the same subject. Yellow lines represent alterations shared by two or more tumor samples. Red lines represent alterations specific to one tumor sample. Green lines represent alterations specific to one normal sample. c Consensus phylogenetic trees for six tumors with at least five samples assayed for both SCNAs and DNA methylation. SNVs, deletions of tumor suppressor genes and amplifications of oncogenes are marked on the inferred phylogenetic tree.
