Fig. 7: Kaplan–Meier curves of overall survival.
From: Genetic and epigenetic intratumor heterogeneity impacts prognosis of lung adenocarcinoma
Kaplan–Meier estimates of overall survival in patients with high and low ITH of a SCNAs, b DNA methylation based on the top 5000 most variable CpG probes and c DNA methylation at CpG islands. d Kaplan–Meier estimates of metastasis in patients with high and low ITH of DNA methylation at CpG islands. High and low ITH groups were stratified by median APITH and colored in red and blue, respectively. The p-values were calculated using the Cox proportional-hazards model weighted by the variance of the estimated APITH. Sample size for each group is indicated in the figure.
