Fig. 4: Gene activity correlates with domain borders and enhancer proximity.
Top of the figure indicates expression level (RPKM) for each of the selected loci at each reprogramming stage35. a Time dependent position of the domain borders as defined by the insulation score analysis on the contact maps derived from the models. The position of the loci in the graph is indicated by a blue horizontal line and its transcriptional orientation is indicated by a blue arrow. b Heat maps of the distances between the TSS particle and all the other model particles as a function of time. c Particles classification into active (A, yellow), active and proximal to the TSS (AP, orange), and active, proximal and within the domain (APD, red). The bottom table shows the number of particles in each category for each reprogramming stage.
