Fig. 2: Fungal immune modulation of DSS-induced colitis.
From: Intestinal fungi are causally implicated in microbiome assembly and immune development in mice
a Experimental layout for DSS study. Seven-week-old gnotobiotic F1 mice were treated with 1.5% DSS for 5 days and colonic inflammation was assessed at end of treatment. A group of colonized animals were not treated with DSS and denoted naive (see Methods). b Percentage weight change between days 1 and 5, spleen weight, and colon length after 5 days of DSS treatment. Measurements of c stool occult blood and d stool Lcn-2 throughout DSS treatment. e Pro-inflammatory cytokines detected in inflamed colon lysates by electrochemiluminescence (MSD). b–e Data expressed as mean ± S.E.M.; color denotes colonization and DSS treatment (Naive = gray, GF = yellow, B = red, Y = green, BY = royal blue); NNAIVE = 7, NGF = 8, NB = 8, NY = 11, NBY = 11; different letters above bars indicate statistically significant differences defined by one-way ANOVA and Tukey post hoc tests; P < 0.05. Source data are provided as a Source data file.
