Fig. 7: Oviductal tumors resemble the molecular subtypes of HG-SOC. | Nature Communications

Fig. 7: Oviductal tumors resemble the molecular subtypes of HG-SOC.

From: Assessing the origin of high-grade serous ovarian cancer using CRISPR-modification of mouse organoids

Fig. 7

a Sample-to-sample heatmap showing the Euclidean distances between the oviductal wild-type organoids, TBP-clones and six independent TBP-clone-derived tumor tissues as calculated from the regularized log transformation. Correlation is based on all the differentially expressed genes between the samples and the pseudocolor scale shows hierarchical distance from minimum (0, dark blue) to maximum (200, white). Clustering assigns the tumors into three distinct clusters (Cluster I, IIa, and IIb). TBP—Trp53, Brca1, Pten mutant. b GSEA showing strong enrichment for genes characteristic to human differentiated- and immunoreactive-like HG-SOCs in different tumor clusters. NES: normalized enrichment score, p-value is a permutation-based p-value that is computed and corrected for multiple testing.

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