Fig. 1: Puma and Noxa deletion rescues oocyte loss in Dmc1 and Msh5 nulls. | Nature Communications

Fig. 1: Puma and Noxa deletion rescues oocyte loss in Dmc1 and Msh5 nulls.

From: The BCL-2 pathway preserves mammalian genome integrity by eliminating recombination-defective oocytes

Fig. 1

a, b P21 ovary sections immunostained for oocyte marker MVH (magenta). Control (Ctrl) is Dmc1+/− Puma+/− Noxa+/−. White rectangles in upper panels show cortex, which is magnified in lower panels. Dotted circles outline degenerated ovaries (n = 5 females, N = 3 experimental repetitions). Scale bar in upper panels 100 μm, scale bars in micrographs 25 μm. c Primordial and total follicle quantitation at P21. Data are represented as mean ± standard deviation. Error bars indicate 95% confidence intervals. Two-sided Mann–Whitney test was used to calculate p-values.

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