Fig. 4: AS dynamics during preimplantation embryo development. | Nature Communications

Fig. 4: AS dynamics during preimplantation embryo development.

From: High-resolution annotation of the mouse preimplantation embryo transcriptome using long-read sequencing

Fig. 4

a Heatmap showing the expression of splicing factors in six stages. Heatmap shows Z-scores of FPKM by row. The representative splicing factors that were activated during 1-cell to 2-cell transition were also presented. b–d Pearson correlation between expression of Raly (b), Phf5a (c), and Snrpd3 (d) and number of AS events in six stages (from oocyte to blastocyst). e The global dynamics of differential splicing events during early embryo development. Each column represents the tracking trace for differential AS events between adjacent stages. Each bar represents the class of differential splicing events. Up: PSI upregulated; down: PSI downregulated; none: AS events showing no difference. f The GO enrichment analysis of biological processes for differential splicing events in adjacent stages. g Heatmap showing the expression of novel transcripts (including novel isoforms and novel genes) that was upregulated during the 1-cell to 2-cell transition. The heatmap shows the Z-score of TPM by row.

Back to article page