Fig. 2: NK cell suppression in MYC-driven lymphomas is systemic and depends on MYC status. | Nature Communications

Fig. 2: NK cell suppression in MYC-driven lymphomas is systemic and depends on MYC status.

From: MYC functions as a switch for natural killer cell-mediated immune surveillance of lymphoid malignancies

Fig. 2

a, b Representative flow cytometry plots depicting percentages of circulating immature CD4+CD8+ T (a) and CD3−NKp46+ NK (b) cells in normal (n = 6), SRα-tTA MYCON (n = 6) and SRα-tTA MYCOFF (doxycycline 96 h, n = 6) mice. c, d Quantification of percentages (c) and absolute counts per μl of blood (d) of CD3−NKp46+ NK cells, in normal (n = 6), SRα-tTA MYCON (n = 6), and SRα-tTA MYCOFF (doxycycline 96 h, n = 6) mice. e Comparison of MFI of surface NKp46 on circulating NK cells in normal (n = 6), SRα-tTA MYCON (n = 6) and SRα-tTA MYCOFF (doxycycline 96 h, n = 6) mice. f, g Representative flow cytometry plots depicting percentages of splenic immature CD4+CD8+ T (f) and CD3−NKp46+ NK (g) cells in SRα-tTA MYCON and SRα-tTA MYCOFF (doxycycline 96 h) mice with comparable blast counts. h Comparison of surface NKp46 levels (MFI) on splenic NK cells from SRα-tTA MYCON and SRα-tTA MYCOFF (doxycycline 96 h) mice with comparable blast counts. i, j Representative flow cytometry plots depicting percentages of circulating immature CD4+CD8+ T (i), and CD3−NKp46+ NK (j) cells in SRα-tTA MYCON and SRα-tTA MYCOFF (doxycycline 96 h) mice with comparable blast counts. k Comparison of surface NKp46 levels (MFI) on circulating NK cells from SRα-tTA MYCON and SRα-tTA MYCOFF (doxycycline 96 h) mice with comparable blast counts. p-values have been calculated using a two-sided Mann–Whitney test. ns not significant. For all box plots, the center is at the median, minima and maxima are indicated by whiskers, and the box represents data between the 25th and 75th percentile.

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