Fig. 2: Substrate scope of simple arenes and heteroarenes.
From: Selective C-H trifluoromethoxylation of (hetero)arenes as limiting reagent
aMethod A: 1 (1.0 equiv), AgF2 (1.0 equiv), TFMS (2) (3.0 equiv), Selectfluor (2.0 equiv), CsF (3.0 equiv), DMC, N2, 35 °C. bMethod B: 1 (1.0 equiv), AgF2 (4.0 equiv), TFMS (2) (4.0 equiv), MeCN, N2, 10 °C. cMethod C: 1 (1.0 equiv), AgF2 (1.0 equiv), TFMS (2) (4.0 equiv), Selectfluor (2.0 equiv), CsF (4.0 equiv), 4-tert-butyl-2,6-bis(4-tert-butylpyridin-2-yl)pyridine (0.1 equiv). DMC, N2, 35 °C. dMethod D: 1 (1.0 equiv), AgF2 (4.0 equiv), TFMS (2) (4.0 equiv), di(pyridin-2-yl)methanone (0.1 equiv), MeCN, N2, 10 °C. eK2S2O8 was used instead of Selectfluor. fYields were determined by the 19F NMR spectrum using benzotrifluoride as internal standards.
