Table 1 Tissue distribution of isotype-switched memory B cells.

From: Discrete populations of isotype-switched memory B lymphocytes are maintained in murine spleen and bone marrow

Hygiene status

Isotype

Spleen

Bone marrow

Peripheral LN

Mesenteric LN

Peyer’s patches

Blood

C57BL/6 SPF

IgA

1976 ± 455

35,634 ± 8754

4304 ± 1398

9090 ± 3290

691 ± 560

53,033 ± 11,414

 

IgG1

392 ± 166

24,390 ± 9098

9995 ± 2127

10,774 ± 3760

3737 ± 1363

63,317 ± 21,266

 

IgG2b

2113 ± 580

106,280 ± 21,839

18,960 ± 9382

44,472 ± 9207

9287 ± 6027

283,616 ± 43,693

pet shop

IgA

2130 ± 590

77,630 ± 39,883

8907 ± 1996

26,300 ± 17,838

13,013 ± 6946

61,850 ± 18,233

 

IgG1

2394 ± 806

148,577 ± 81,700

36,323 ± 10,256

58,646 ± 17,547

17,609 ± 6470

222,179 ± 59,635

 

IgG2b

9827 ± 2565

425,361 ± 223,940

147,720 ± 25,912

221,403 ± 42,907

136,631 ± 44,282

1,385,442 ± 390,533

feral

IgA

2169 ± 952

12,904 ± 3853

340 ± 202

3602 ± 733

3758 ± 1624

12,873 ± 5428

 

IgG1

2877 ± 713

38,719 ± 12,991

797 ± 348

53,537 ± 19,914

2305 ± 784

55,717 ± 19,544

 

IgG2b

7373 ± 1882

73,974 ± 27,089

1321 ± 467

75,657 ± 28,597

4503 ± 1070

104,652 ± 37,075

  1. Mean values (±SEM) of IgG1+, IgG2b+ and IgA+ CD19+CD138−CD38+CD11c−GL7−IgM−IgD− small lymphocytes; total cell numbers as calculated per organ. N = 42 (from eight experiments with five different immunizations protocols performed in C57BL/6 mice aged 4–20 months and held under SPF conditions), 13 (feral) and 13 (pet shop).
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