Fig. 4: Analysis results of mTADA for pairs of disorders.
From: mTADA is a framework for identifying risk genes from de novo mutations in multiple traits
a The estimated gene-level genetic overlaps (gOs) of pairs of disorders from Markov Chain Monte Carlo sampling results. Each par shows the credible interval and the black dot is the estimated value. The vertical black line describes g0 = 50%. b The estimated proportion of overlapping risk genes (π3) in the mTADA model. c Comparison of mTADA and extTADA in the prioritization of top genes by using a threshold of posterior probability (PP) > 0.8. In mTADA, the column ‘First trait’ and ‘Second trait’ are inferred by summing the PPs of model 1 and 3 (PP1 + PP3), and model 2 and model 3 (PP2 + PP3) in Fig. 1 respectively. d These genes appear in at least 4 pairs of disorders (PP > 0.8). Cells show the PP values. Y-axis shows gene names and x-axis describes pairs of disorders.
