Fig. 3: Humoral responses to SARS-CoV-2 and SARS-CoV antigens in BALB/c mice after a single dose of INO-4800.
From: Immunogenicity of a DNA vaccine candidate for COVID-19
BALB/c mice were immunized on day 0 with indicated doses of INO-4800 or pVAX-empty vector as described in the methods. a Protein antigen binding of IgG at 1:50 and 1:250 serum dilutions from mice at day 14 immunized with 25 µg of INO-4800 or pVAX. Data shown represent mean OD450 nm values (mean + SD) for each group of 3 mice. b SARS-CoV-2 S1 + 2 or c SARS-CoV-2 RBD protein antigen binding of IgG in serial serum dilutions from mice at day 14. Data shown represent mean OD450 nm values (mean + SD) for each group of eight mice (b, c) and five mice (d, e). Serum IgG binding endpoint titers to (c) SARS-CoV-2 S1 + 2 and (e) SARS-CoV-2 RBD protein. Data representative of two independent experiments. Values depicted are mean +/− SD. P values determined by Mann–Whitney test.
