Fig. 4: Variance attributable to tissue-specific gene expression.
From: Bayesian reassessment of the epigenetic architecture of complex traits
a, b Variance explained by probes that have tissue-specific differentiated gene expression in Genotype-Tissue Expression (GTEx) project. Variance explained is decomposed by the mixture to which the posterior effects belong. For both traits, the biggest contribution comes from probes not mapped into genes differentially expressed in GTEx (not shown). From the probes that mapped into differentially expressed genes, in smoking, the biggest mixture (1% of the total variance explained by probes) captures probes mapping to genes differentially expressed in tibial and aorta arteries, along with the spinal cord, indicating these contribute more than what is observed by the rest of the probes among tissues and mixtures. For BMI, no such difference in effects distribution was observed among mixtures and among tissues.
