Table 1 R2(%) in replication study.

From: Bayesian reassessment of the epigenetic architecture of complex traits

Trait

Method

LBC1936

TwinsUKa

A.0

A.7

A.15

A.FOF

A.FOM.

BMIb

LASSO

18.7

–

1.07

0.13

2.95

9.37

14.95

 

Bayes

19.5

30.83/9.33

3.34

2.05

9.65

18.36

24.45

Smokingc

LASSO

42.18d

–

–

–

–

24.71

–

 

Bayes

47.9

–

–

–

–

38.49

–

  1. A phenotypic predictor was created in the Lothian Birth Cohort data 1936 (LBC1936) and Accessible Resource of Integrated Epigenomics Studies (ARIES) cohorts from the methylation effects estimated in the Generation Scotland (GS) data. The prediction accuracy as measured by the R2 statistic is presented as compared with LASSO estimates of the methylation effects. In the ARIES cohort, A.0 refers to measures at birth, A.7 refers to measures at age 7, A.15 refers to measures at age 15, A.FOF refers to adult males (fathers), and A.FOM refers to females (mothers).
  2. aWhole blood/adipose tissue.
  3. blog(kg/m2).
  4. clog(p.p.y.+1).
  5. dEstimates from GS wave 1, n = 5000.
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