Fig. 5: Molecular bases of the Alzheimer’s disease—non-small-cell lung cancer comorbidity relations.

Positive and negative Relative Molecular Similarity (pRMS and nRMS) interactions between Alzheimer’s disease and non-small-cell lung cancer subgroups composed by at least four patients with shared genes (extracted from the Stratified Comorbidity Network). Each node represents a patient-subgroup. Red and blue edges represent negative and positive interactions respectively. Solid lines represent interactions between subgroups while dashed lines represent patient-subgroup—gene/pathway interactions. Only those genes (and pathways; see “Methods”) associated to positively or negatively connected patient-subgroups are shown (see “Methods”).