Fig. 7: The Disease PERCEPTION portal.

Through this user-friendly and programmatically accessible portal, the user can visualize comorbidity relations at the disease and patient-subgroup levels. Moreover, users can extract patient-subgroup information, filtering by subgroup size, intra-subgroup connectivity, as well as by shared drugs and/or genes. Genes and drugs in the networks are hyperlinked to databases, facilitating an interactive exploration of the molecular basis of each connection. a Disease network view. Each node represents a disease, colored based on the disease category it belongs to. Blue and red edges denote positive and negative Relative Molecular Similarity (pRMS, nRMS) interactions. Relative risk cut-off can be modified. b AD neighbors view. Desired diseases can be selected to show their patient-subgroups. c AD and NSCLC patient-subgroups with >4 patients per subgroup. d Same as c excluding intra-disease interactions. e Same as c showing only patient-subgroup interactions with shared drugs. Selecting edges of interest displays genes and drugs potentially involved in the selected interactions.