Fig. 3: Selective CDK7 and CDK2 inhibitors.
a Live cell engagement potency for CDK7 selective probes. Reported IC50 data are the mean of 3 independent experiments ± S.E.M. (Supplementary Data 2). Blank cells represent IC50 values that failed to meet our criteria of potency (< 1 µM) or occupancy (≥ 50% at 10 µM). b Upper: Target engagement of CDK7-selective inhibitors. A representative single technical replicate (n = 1) of live cell target occupancy results from 3 independent experiments (Supplementary Data 2). Lower: Compound structures and dendrogram-based illustration of engagement selectivity for CT7001 and BS-181 against the complete CDK family. c Upper: Target engagement of NU6102 against CDK2. A representative technical replicate (n = 1) of target occupancy results from 3 independent experiments is shown (Supplementary Data 2). Potency of putative targets CDK1 and CDK4 are shown for comparison. Lower: Chemical structure and dendrogram-based illustration of engagement selectivity for NU6102. Source data are provided as a Source Data file.
