Table 5 List of significant metabolites among groups at T2.

From: Analysis of immune, microbiota and metabolome maturation in infants in a clinical trial of Lactobacillus paracasei CBA L74-fermented formula

 

F value

P value

−LOG10(p)

FDR

Fisher’s LSDa

l-Ascorbic acid

8.3458

9.77E-06

5.0101

0.00087

CF-CS; VS-CS; VF-CS; CF-CBM; CF-VBM; VS-CBM; VF-CBM; VS-VBM; VF-VBM

N-acetyl-d-glucosamine

7.6955

2.23E-05

4.6516

0.000992

VBM-CS; VBM-CF; VBM-CBM; VBM-VS; VBM-VF

l-Methionine

6.9005

6.34E-05

4.198

0.001881

CBM-CS; CBM-CF; CBM-VS; CBM-VF; CBM-VBM

Arabitol 4

6.5741

9.85E-05

4,0065

0.002192

CBM-CS; VBM-CS; CBM-CF; VBM-CF; CBM-VS; VBM-VS; VBM-VF

l-Threonine

6.2239

0.000159

3.7977

0.002836

CS-CBM; CS-VF; CS-VBM; CF-VBM; VS-CBM; VS-VF; VS-VBM

2–3-Butanediol

5.9549

0.000232

3.6348

0.003439

CBM-CS; CBM-CF; CBM-VS; CBM-VF; CBM-VBM

5-Dimethylaminomethyl 1H-pyrrole-2-carboxylic acid–methyl ester

5.1082

0.000779

3.1082

0.009822

CS-CF; CS-CBM; CS-VS; CS-VF; CS-VBM

Galactitol-2-amino-2-deoxy- N-acetyl

5.0231

0.000883

3.0541

0.009822

CBM-CS; VBM-CS; CBM-CF; CBM-VS; CBM-VF; VBM-VS; VBM-VF

2-Alpha-mannobiose 2

4.5294

0.001837

2.736

0.018161

CS-CF; CS-CBM; CS-VS; CS-VF; VBM-CF

2–3-Dihydroxy-2-methylpropanoic acid

4.4544

0.002056

2.687

0.018296

CBM-CS; VBM-CS; CBM-CF; VBM-CF; CBM-VS; CBM-VF; VBM-VS; VBM-VF

d-Allose 1

4.1187

0.00342

2.466

0.027669

VBM-CS; VBM-CF; CBM-VF; VBM-VS; VBM-VF

l-Valine

3.9443

0.004467

2.35

0.033133

CS-CBM; CS-VBM; VS-CBM; VS-VBM

2-Butenedioic acid

3.8178

0.005429

2.2653

0.035468

CS-CBM; CS-VF; CS-VBM; VS-CBM; VS-VBM

d-Psicofuranose

3.7758

0.005793

2.2371

0.035468

VBM-CS; CBM-CF; VBM-CF; CBM-VS; CBM-VF; VBM-VS; VBM-VF

2-Hydroxyisocaproic acid

3.7555

0.005978

2.2235

0.035468

CS-CBM; CS-VF; CS-VBM; CF-CBM; CF-VF; CF-VBM

Arabinose

3.6773

0.006749

2.1708

0.037539

VS-CS; VS-CF; VS-CBM; VS-VF; VS-VBM

N-acetyl-d-galactosamine 3

3.596

0.007658

2.1159

0.040093

VBM-CS; VBM-CF; VBM-CBM; VBM-VS; VBM-VF

Glyceryl-glycoside

3.5171

0.008661

2.0624

0.042822

VBM-CS; VBM-CF; VBM-VS; VBM-VF

Beta-l-Fucopyranose 2

3.4277

0.00996

2.0017

0.043722

VBM-CF; VBM-CBM; VBM-VS; VBM-VF

2-Ketoisocaproic acid

3.421

0.010065

1.9972

0.043722

CS-CBM; CS-VBM

d-Glucose 3

3.4052

0.010316

1.9865

0.043722

VBM-CS; VBM-CF; VBM-CBM; VBM-VS; VBM-VF

l-Leucine

3.3595

0.011084

1.9553

0.04484

VS-CBM; VS-VBM

l-Threose 2

3.2792

0.012573

1.9006

0.048651

CS-CBM; CS-VS; CS-VF; CS-VBM

  1. ANOVA analysis (FDR < 0.05) at T2 according to diet and delivery groups.
  2. aComparisons between groups with significant post hoc analysis (Fisher’s LSD < 0.05).
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