Fig. 3: Differential analysis in metabolite abundance levels between ICM or DCM and donors.
From: Core functional nodes and sex-specific pathways in human ischaemic and dilated cardiomyopathy
a PCA of metabolomic data in ICM and DCM, including all three conditions and both genders. b Volcano plot of ICM vs Donor metabolites. Estimates were derived using the linear regression model adjusted for gender, where nICM = 15 and ndonor = 15. c Volcano plot of DCM v Donor metabolites. Estimates were derived using the linear regression model adjusted for gender, where nDCM = 14 and ndonor = 15. d Venn Diagram summarising the differential and overlapping metabolites. e Plot of fold changes of metabolites in ICM, DCM, and both. f Multigroup heatmap with dendrogram of DE metabolite levels incorporating donor, ICM, and DCM hearts and both genders. Source data are provided as a Source Data file.
