Fig. 5: Crystallography-based fragment screening of hsALAS2. | Nature Communications

Fig. 5: Crystallography-based fragment screening of hsALAS2.

From: Human aminolevulinate synthase structure reveals a eukaryotic-specific autoinhibitory loop regulating substrate binding and product release

Fig. 5

a ALAS2-bound fragments are clustered into distinct regions of the protein. The two subunits of an ALAS2 homodimer are colored green and yellow. b Chemical structures of the fragments 1–9, which are bound in proximity to the hsALAS2 Ct-extension. c Close-up view of the Ct-extension region of one subunit (green) and its neighboring subunit (yellow), showing the binding modes of fragments 1–9. For fragment 9, the second molecule (9′) bound to the yellow dimeric subunit is also shown.

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