Fig. 6: Graphical Summary.
From: Dynamics of the 4D genome during in vivo lineage specification and differentiation
Based on our findings, we propose a model in which TADs are established very early in differentiation. During lineage commitment, tissue-specific open chromatin sites are established within these domains. This is followed by the formation of smaller sub-domains within TADs, in which enhancers and promoters form interactions. Through differentiation, accessibility and specific interactions between enhancers and promoters are gradually increased, concomitant with upregulation of gene expression.
