Fig. 5: V1-projecting OFC neurons reduce activity during reward expectation.
From: Orbitofrontal control of visual cortex gain promotes visual associative learning
a Schematic of the strategy for phototagging V1-projecting OFC neurons. b Spike raster of an identified V1-projecting OFC neuron aligned to laser onset. Red bar, duration of laser stimulation. Top, mean waveforms for spontaneous (black) and laser-evoked (red) spikes. c PSTHs aligned to laser onset (blue line) for all identified neurons. The responses were normalized by peak value and sorted by peak latency. Colors from black to white indicate increase in firing rate. d Cumulative distribution of laser-evoked spike latency for all identified neurons. e Spike rasters and PSTHs of an identified V1-projecting OFC neuron during hit (green), FA (red) and CR (blue) trials, aligned to stimulus onset. f The firing rates of each neuron were normalized by the maximum of the peak values in hit, FA, and CR trials, and were averaged across neurons. Horizontal bar, timepoints with P < 0.05, two-way repeated measures ANOVA F(1,21)  = 17.86, P = 3.79 × 10−4 followed by Sidak’s multiple comparisons test. g Distribution of MIs for identified V1-projecting OFC neurons. P = 6.9 × 10−4, n = 22 neurons, Wilcoxon two-sided signed rank test. For c–g, source data are provided as a Source Data file. Shadings, mean ± s.e.m.
