Fig. 4: SRC correlates with Bcl-2 expression but not with CD8+ T cell functionality. | Nature Communications

Fig. 4: SRC correlates with Bcl-2 expression but not with CD8+ T cell functionality.

From: Metabolic characteristics of CD8+ T cell subsets in young and aged individuals are not predictive of functionality

Fig. 4

a Percent lysis of OVA-loaded targets by sorted TN, TVM and TMEM cells from young or aged OT-I mice (n = 3–8). * Indicates p ≤ 0.05, ** indicates p ≤ 0.01, unpaired t test, data are representative of at least 3 individual experiments. Simple linear regression analyses of mean SRC from Fig. 1b against b the mean number of divisions of sorted CD8+ T cells following 60 h TCR stimulation from ref. 17, c the average percent lysis from (a), d the average proportion of sorted CD8+ T cells making IFN-γ at 36 h after TCR stimulation from ref. 17, and e the median fluorescence intensity (MFI) of Bcl-2 expression from ref. 17.

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