Fig. 2: Topology diagram of the T4CC hetero-pentameric core structure.

Color-coding for DotL, DotM, DotN, DotZ, and DotY is as in Fig. 1e. IcmS and IcmW are in magenta and purple, respectively. Strands and helices are represented as arrows and cylinders, respectively. Secondary structures are labelled, as well as N- and C-termini. For DotL, NBD and AAD stands for nucleotide-binding and all alpha-helical domains, respectively. The location of the DotL channel in the hexamer and the cavity in which the DotM-bound Glu-rich SP inserts are indicated.