Fig. 3: Assembly of the T4CC.
a Locations of the various protein-protein interfaces shown in (b–i). In all panels, secondary structures involved in interactions are labelled. b The DotL-DotM interface. At left, DotL and DotM are shown in red ribbon and cyan surface, respectively. At right, DotM and DotL are shown in cyan ribbon and red surface, respectively. c The DotL-DotM interface (continued). This view focuses on the β11α14 part of the DotL tail (in red ribbon) which here interacts with a groove of DotM (in cyan surface) between two of its domains. d Interaction between the α14 to α16 part of the DotL tail (in red ribbon) with DotN (in blue ribbon). e The DotM-DotN interface. DotM and DotN are shown in cyan and blue ribbon, respectively. f Structure of DotZ (orange yellow ribbon) and its interface with DotN (blue ribbon) and DotM (cyan ribbon). All secondary structures in DotZ are labelled as well as its N- and C-terminus. g Details of the interface between DotZ (in orange yellow surface) and DotN (in blue ribbon) and DotM (in cyan ribbon). A groove between α1 and α3 is clearly visible in DotZ, into which α8 of DotN inserts. DotM makes contact with DotZ via the long β1β2 loop. h β1β2 of DotM together with α3β3 of DotN and α8 of DotZ form a cavity located just below the Glu-rich effector signal peptide binding site on DotM. i Interface between DotY (in green ribbon), DotN (in blue ribbon) and DotZ (in orange yellow surface).
