Fig. 4: Differences in fine-scale volume growth trajectories after accounting for ICV.

Replicating the analysis of Fig. 3 and Table 2 at a voxel level using deformation tensor morphometry: Axial slices (right in image is subject left) showing quantitative size (left column) and T-statistic maps (middle column) of the sex differences and any age interactions (right column), overlaid on the average MRI estimate at the average age (27.8 GWs). Blue-cyan indicates points where males have relatively larger volume over the 18 GWs after accounting for global ICV, and red-yellow indicates locations where females have relatively greater volume than males. For the T-statistic maps the darkest red and blue indicate those points surviving correction for multiple comparisons with two-sided significance (P < 0.05) marked on the upper right scale. Specific regions highlighted: CING: cingulate sulcus, OC: occipital cortex, SPL: splenium, INS: insular cortex.