Fig. 1: Mutational spectrum of CHIP in hematopoietic cells of multiple myeloma patients at the time of autologous stem cell transplant.

a The total number of patients harboring one or more mutations in each gene. b Number of patients harboring mutations in 1, 2, and 3 different genes. c Comutation plot showing mutations present in all 136 patients: each column represents a single patient. The top row denotes the maximum VAF in each patient, with darker shades of red indicating higher VAF. The VAF cutoff used to call mutations was 0.01. The bar graph on the right designates the percentage of the different mutation subtypes for each gene out of all detected CHIP mutations.