Table 1 Patient characteristics.
Characteristics | CHIP | |||
|---|---|---|---|---|
Total | No | Yes | p-value | |
n = 629 (%) | n = 493 (78) | n = 136 (22) | ||
Age at transplant | ||||
Median (range) | 58 (24–83) | 57 (24–72) | 61 (34–83) | <0.001† |
20–29 | 2 (0) | 2 (0) | — | <0.001§ |
30–39 | 16 (3) | 14 (3) | 2 (1) | |
40–49 | 89 (14) | 82 (17) | 7 (5) | |
50–59 | 251 (40) | 203 (41) | 48 (35) | |
60–69 | 252 (40) | 182 (37) | 70 (51) | |
70–79 | 19 (3) | 10 (2) | 9 (7) | |
Sex | ||||
Female | 268 (43) | 219 (44) | 49 (36) | 0.096‡ |
Male | 361 (57) | 274 (56) | 87 (64) | |
Race | ||||
Asian | 3 (0) | 3 (1) | — | 0.97‡ |
Black | 21 (3) | 16 (3) | 5 (4) | |
Hispanic/Latino | 10 (2) | 8 (2) | 2 (1) | |
Native American | 2 (0) | 2 (0) | — | |
Other | 6 (1) | 4 (1) | 2 (1) | |
Unknown | 11 (2) | 9 (2) | 2 (1) | |
White | 576 (92) | 451 (91) | 125 (92) | |
Myeloma subtype | ||||
Biclonal | 5 (1) | 3 (1) | 2 (1) | 0.42‡ |
IgA Kappa | 69 (11) | 55 (11) | 14 (10) | |
IgA Lambda | 50 (8) | 41 (8) | 9 (7) | |
IgA-only | 7 (1) | 6 (1) | 1 (1) | |
IgG Kappa | 247 (39) | 199 (40) | 48 (35) | |
IgG Lambda | 93 (15) | 67 (14) | 26 (19) | |
IgG-only | 15 (2) | 12 (2) | 3 (2) | |
Kappa-only | 73 (12) | 61 (12) | 12 (9) | |
Lambda-only | 55 (9) | 38 (8) | 17 (12) | |
Non-secretory | 15 (2) | 11 (2) | 4 (3) | |
0–25 | 141 (22) | 114 (23) | 27 (20) | 0.81§ |
26–50 | 158 (25) | 120 (24) | 38 (28) | |
51–75 | 142 (23) | 108 (22) | 34 (25) | |
76–100 | 158 (25) | 129 (26) | 29 (21) | |
ISS | ||||
1 | 353 (56) | 282 (57) | 71 (52) | 0.67§ |
2 | 170 (27) | 123 (25) | 47 (35) | |
3 | 106 (17) | 88 (18) | 18 (13) | |
Bone marrow involvement post-induction (percent) | ||||
0–25 | 488 (78) | 380 (77) | 108 (79) | 0.18§ |
26–50 | 43 (7) | 33 (7) | 10 (7) | |
51–75 | 18 (3) | 12 (2) | 6 (4) | |
76–100 | 12 (2) | 7 (1) | 5 (4) | |
Missing | 68 (11) | 61 (12) | 7 (5) | |
Induction therapy | ||||
Bortezomib | 212 (34) | 167 (34) | 45 (33) | 0.90‡ |
Cyclophosphamide | 73 (12) | 56 (11) | 17 (12) | |
Lenalidomide/Thalidomide | 304 (48) | 240 (49) | 64 (47) | |
Other | 40 (6) | 30 (6) | 10 (7) | |
Number of therapies prior to induction | ||||
0 | 434 (69) | 339 (69) | 95 (70) | >0.99§ |
1 | 118 (19) | 97 (20) | 21 (15) | |
2 | 44 (7) | 32 (6) | 12 (9) | |
3+ | 33 (5) | 25 (5) | 8 (6) | |
Family history of any cancers | ||||
No | 210 (33) | 162 (33) | 48 (35) | 0.61‡ |
Yes | 419 (67) | 331 (67) | 88 (65) | |
Smoking | ||||
No | 394 (63) | 319 (65) | 75 (55) | 0.043‡ |
Yes | 228 (36) | 168 (34) | 60 (44) | |
Missing | 7 (1) | 6 (1) | 1 (1) | |
