Fig. 3: Fluorescence images of different tumor tissue slices. | Nature Communications

Fig. 3: Fluorescence images of different tumor tissue slices.

From: Exploiting metabolic acidosis in solid cancers using a tumor-agnostic pH-activatable nanoprobe for fluorescence-guided surgery

Fig. 3

Head and neck squamous cell cancer of the tongue (a–f); breast cancer (g–l); esophageal cancer (m–r); colorectal cancer (s–x). The tumor is delineated as a solid black line in the H/E slices (c, i, o, u). The mean fluorescence intensity (MFI) of the tumor tissue and the non-tumor tissue slices, per tumor type, is depicted (y). The dots represent the MFI of single tissue slices (≈3 per subject) from the 1.2 mg per kg cohort. HNSCC, 7 subjects, P < 0.0001, BC, 5 subjects, P = 0.0001, EC, 3 subjects, P = 0.0010, and Wilcoxon test, two-sided. CRC, 3 subjects, no statistics performed due to the availability of only three data points. HNSCC head and neck squamous cell cancer, BC breast cancer, EC esophageal cancer, CRC colorectal cancer, H/E hematoxylin eosin. ***P ≤ 0.001; ****P ≤ 0.0001. Source data are provided as a Source data file.

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