Fig. 8: Top3β-KO mice have reduced Pol II signals in genes important for synapse and neurogenesis. | Nature Communications

Fig. 8: Top3β-KO mice have reduced Pol II signals in genes important for synapse and neurogenesis.

From: Topoisomerase 3β knockout mice show transcriptional and behavioural impairments associated with neurogenesis and synaptic plasticity

Fig. 8

a, b Lists of top10 negative GO terms (gene sets) identified using Log2 fold changes between Pol II signals at TSS of Top3β-KO vs. those of WT mice, without (a) or with FC treatment (b). Red and blue arrows indicate GO terms related to neurogenesis and synapse, respectively. c A graph shows 18 well-studied synapse-related genes (Pubmed citation ≥ 20) that have stronger reduction Pol II signals at exons in Top3β-KO mice treated with FC (P < 0.01) than that without the treatment. Log2_ratios of signals between Top3β-KO vs. the WT mice are shown. 2-way ANOVA test was performed for this and other graphs. d A graph shows 10 well-studied synapse-related genes (Pubmed ctation ≥ 20) that have at least 1.5-fold induction in WT mice by FC (p < 0.05), but not in Top3β-KO. Log2_ratios of signals between FC-treated and untreated mice are shown. e, f Same as (c, d), except that the data from well-studied neurogenesis-related genes are shown. Error bars represent standard errors (ANOVA). The data are from four pairs of untreated mice, and five pairs of FC-treated mice. Source data are provided as a Source Data file, which describes detailed calculations including p-values.

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