Fig. 7: Synthesis of β-ketoamides via transformation of N-Boc amides using 1,1-diborylalkanes.
From: Chemodivergent transformations of amides using gem-diborylalkanes as pro-nucleophiles
Reaction conditions: 1 (0.45 mmol), MeLi (0.45 mmol), THF (3.0 mL), 0 °C, 30 min then N-Boc amides T5 (0.30 mmol), B(OiPr)3 (0.30 mmol), 80 °C for 2 h. a10.0 mmol scale. Yields based on isolated products. bThe d.r. value was not determined.
