Fig. 1: Local genetic correlation between migraine and BP traits at reported migraine loci using ρ-HESS and GWAS-PW.
From: A genome-wide cross-phenotype meta-analysis of the association of blood pressure with migraine
Colors represent the significance level of local genetic correlation between migraine and blood pressure (BP) traits (DBP, SBP, and PP) using ρ-HESS (Pρ-HESS based on Wald test), red for positive genetic correlation and blue for negative genetic correlation at the corresponding locus. Dots represent the estimated posterior probability (PPA_3) that genetic associations with migraine and BP traits (DBP, SBP, and PP) co-localize at the corresponding locus, larger size indicate larger posterior probability. Significant local genetic correlation between BP traits and migraine was observed at three regions: harboring gene FHL5, C7orf10, and PLCE1, after controlling for multiple testing (Pρ-HESS < 0.05/1703, see details in Supplementary Table 1) and with high estimated posterior probability (PPA_3 > 0.9, see details in Supplementary Table 2).
