Fig. 5: Structural details of the SC lateral element revealed by MAP-SIM of SYCP3.
From: Tracking down the molecular architecture of the synaptonemal complex by expansion microscopy
a–c, f, g The SYCP3 signal shows occasional bifurcation along the two SC strands (I–IV) and various degrees of fraying at their ends depending on the respective pachytene stage (1–4). e Unpaired regions of the XY pair (arrowheads) also show a strong degree of fraying. d, h Schematic representations of early EM reports of two or more sub lateral elements (subLEs) in mammals46,48 in accordance with the splitting of the SYCP3 signal resolved by MAP-SIM in this study. d Representation of the lateral element strand splitting in two and fraying at its end according to literature46,48. h Fraying of LEs associated with unpaired regions of the XY pair modeled according to literature48. Scale bars, (a, b) 7 µm, (c) 1.5 µm, (e–f) 7 µm, (g) 1.5 µm.
