Fig. 6: Transcriptional analysis of CD4+ Tconvs and Tregs from NI and I TDLNs, and tumor. | Nature Communications

Fig. 6: Transcriptional analysis of CD4+ Tconvs and Tregs from NI and I TDLNs, and tumor.

From: Tumor invasion in draining lymph nodes is associated with Treg accumulation in breast cancer patients

Fig. 6

RNA-sequencing analysis of bulk sorted T-memory CD4+ Tconvs and Tregs from matched NI and I TDLNs and the primary tumor. a Venn diagram and b pathway analysis of differentially expressed genes (DEG, fold change 1.2, p < 0.05) between Tregs and Tconvs in NI TDLNs, I TDLNs and tumors. c, d Heatmaps showing 50 DEGs common to Treg and Tconvs from the three tissues c or specific to each tissue d. Red and blue indicate higher and lower expression, respectively. Family gene names are indicated (left). Cell adhesion: cell adhesion molecules. Ig superfamily: immunoglobulin superfamily domain containing. TNFR receptor superfamily: tumor necrosis factor receptor superfamily. TNFR-associated factors: tumor necrosis factor receptor-associated factors. IFN receptors: interferon receptors. IFN regulatory factors: interferon regulatory factors.

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